TB-500 Frag 17-23 — 10mg

TB-500 Frag 17-23 is the short active fragment of Thymosin Beta-4: the seven-residue LKKTETQ sequence spanning positions 17 to 23 of the parent peptide, supplied in N-terminally acetylated form. This region is the actin-binding domain, and published analytical work has identified the acetylated 17-23 fragment as the species present in material sold commercially as TB-500.

This is a distinct product from Durham Peptides' TB-500 10mg, which supplies the full-length 43-amino-acid Thymosin Beta-4 peptide. Researchers choosing between them are choosing between the isolated active fragment and the complete parent molecule — a meaningful distinction for work on structure-activity relationships.

BENEFITS

• Isolated active domain — the actin-binding region without the rest of the parent peptide

• Short and well-defined — seven residues, unambiguous structure, simple synthesis

• Structure-activity work — pairs directly against full-length Thymosin Beta-4

• Analytically characterised — the acetylated 17-23 species is documented in the literature

• Verified identity — MS-confirmed against a Janoshik report you can check independently

WHAT RESEARCHERS LOOK AT

• Actin binding and polymerisation attributable to the 17-23 domain alone

• Fragment vs full-length activity in parallel study arms

• Cell migration and wound-healing models in preclinical systems

• Stability and handling differences of a heptapeptide vs a 43-residue peptide

• Analytical identification of fragment species in commercial TB-500 material

QUICK SPECS

• Form: Lyophilized peptide powder

• Net per vial: 10 mg

• Purity: ≥99% (HPLC verified)

• Identity: MS-verified (per COA)

• Storage: 2–8°C, protect from light and moisture

• Reconstitution: Use bacteriostatic water (sold separately)

IDENTITY BASICS

• Compound: Acetylated Thymosin Beta-4 fragment 17-23

• Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ, 7 residues)

• Parent compound: Thymosin Beta-4, CAS 77591-33-4 (43 amino acids)

• Molecular weight and batch CAS: as stated on the batch COA

• Also written as: TB-500 fragment 17-23, Ac-LKKTETQ, TB4 Frag 17-23

WHY CHOOSE DURHAM PEPTIDES FOR TB-500 FRAG 17-23?

• Janoshik tested with independently verifiable COA keys

• Both the fragment and full-length Thymosin Beta-4 stocked, clearly distinguished

• Same-day shipping across Canada (orders before 5:00 PM EST)

• Free shipping on orders over $200 CAD

• 100% vegan — synthetically manufactured, no animal derivatives

• Transparent Canadian pricing, shown above in CAD

SELECTED RESEARCH

• Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500 (PubMed 22962027)

• Thymosin Beta-4 and tissue repair (PubMed 10469335)

WHAT IS TB-500 FRAG 17-23?

It is the seven-residue LKKTETQ sequence from positions 17 to 23 of Thymosin Beta-4, supplied in N-terminally acetylated form. This region is the actin-binding domain of the parent peptide, and published analytical work has identified the acetylated 17-23 fragment as the species present in commercial TB-500 material.

TB-500 FRAG 17-23 VS TB-500 (FULL THYMOSIN BETA-4) — WHAT'S THE DIFFERENCE?

Length. The fragment is seven amino acids — just the actin-binding domain. Durham Peptides' TB-500 10mg supplies the full-length 43-amino-acid Thymosin Beta-4 peptide. Researchers pick between them depending on whether the work isolates the active domain or uses the complete parent molecule; the two are commonly run in parallel for structure-activity comparisons.

WHY IS THE FRAGMENT ACETYLATED?

N-terminal acetylation is a standard modification that alters a short peptide's stability profile. It is also the form documented in the analytical literature on TB-500 material, which is why the acetylated fragment rather than the bare sequence is the one supplied for research.

HOW SHOULD IT BE STORED AND RECONSTITUTED?

Store the lyophilized vial at 2–8°C, protected from light and moisture. Reconstitute with bacteriostatic water (sold separately) for research handling. Once reconstituted, keep refrigerated and use within an appropriate research timeframe.

HOW IS IT SHIPPED IN CANADA?

Orders placed and paid before 5:00 PM EST ship the same business day via Canada Post Xpresspost with full tracking. Shipping is domestic from within Canada, so there are no customs delays or border holds.

IS THE COA VERIFIABLE?

Yes. Every batch is Janoshik-tested with a unique report key you can confirm independently — see our guide on how to verify a Janoshik unique key.

• For laboratory research use only.

• Not for human or veterinary use.

• Not intended for diagnosis, treatment, cure, or prevention of any disease.

• Use only in controlled laboratory settings by qualified personnel following appropriate safety procedures.