KPV — 10mg

KPV (Lys-Pro-Val) is the C-terminal tripeptide fragment (residues 11-13) of alpha-melanocyte-stimulating hormone (α-MSH), one of the most studied endogenous anti-inflammatory peptides. Unlike full-length α-MSH, KPV retains anti-inflammatory signaling activity without melanocortin receptor-mediated pigmentation effects. Research has shown that KPV enters cells via the PepT1 di/tripeptide transporter and directly modulates intracellular NF-κB and MAP kinase signaling pathways. It has been studied extensively in gastrointestinal inflammation models including DSS and TNBS colitis. Durham Peptides also carries BPC-157, another peptide studied in gastrointestinal research contexts.

BENEFITS

• Anti-inflammatory signaling — studied for NF-κB and MAPK pathway inhibition at nanomolar concentrations

• Intestinal barrier research — explored for mucosal protection and epithelial barrier function

• Pigmentation-free — retains α-MSH anti-inflammatory activity without melanocyte stimulation

• PepT1-mediated transport — studied for intracellular uptake via the di/tripeptide transporter

• Antimicrobial research — investigated for effects against S. aureus and C. albicans in preclinical models

WHAT RESEARCHERS LOOK AT

• NF-κB and MAP kinase signaling inhibition in intestinal epithelial cell models

• Pro-inflammatory cytokine suppression (TNF-α, IL-6, nitric oxide production)

• PepT1 transporter-mediated intracellular uptake mechanisms

• DSS and TNBS colitis models (oral administration studies)

• Wound healing and scar formation in dermal research models

QUICK SPECS

• Form: Lyophilized peptide

• Net per vial: 10 mg

• Purity: ≥99% (HPLC verified)

• Identity: MS-verified (per COA)

• Storage: 2–8°C short-term, -20°C long-term, protect from light and moisture

• Reconstitution: Use bacteriostatic water (sold separately)

IDENTITY BASICS

• Sequence: Lys-Pro-Val (tripeptide)

• Molecular Formula: C₁₆H₃₀N₄O₄

• Molecular Weight: 342.43 g/mol

• CAS Number: 67727-97-3

• Common Synonyms: ACTH(11-13), α-MSH(11-13), KPV Tripeptide

WHY CHOOSE DURHAM PEPTIDES FOR KPV?

• independently lab-tested with verifiable COA keys

• Same-day shipping across Canada (orders before 5:00 PM EST)

• Free shipping on orders over $200 CAD

• 100% vegan — synthetically manufactured, no animal derivatives

• Secure payment via Interac e-Transfer, credit/debit, or Crypto

SELECTED RESEARCH

• Dalmasso et al. — PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation: https://pubmed.ncbi.nlm.nih.gov/18451268/

• Brzoska et al. — α-MSH related peptides: a new class of anti-inflammatory drugs: https://pubmed.ncbi.nlm.nih.gov/17934098/

• Luger et al. — New insights into the functions of α-MSH and related peptides in the immune system: https://pubmed.ncbi.nlm.nih.gov/12665159/

• For laboratory research use only.

• Not for human or veterinary use.

• Not intended for diagnosis, treatment, cure, or prevention of any disease.

• Use only in controlled laboratory settings by qualified personnel following appropriate safety procedures.

Volume discounts apply to your whole order, not to a single item. Enter the code at checkout.

• Spend $200 or more — 10% off with code VOLUME10

• Spend $500 or more — 15% off with code VOLUME15

• Spend $1,000 or more — 20% off with code VOLUME20

The thresholds are worth more than they look. A $499 order costs you $449. Add one more $20 vial to reach $500 and you pay $425 — more product, $24 less. Free shipping over $200.

Ordering at volume? The full catalogue is available at wholesale pricing through a five-tier programme.

• Minimum 10 units per product, any mix of products in one order

• Accounts open at $2,000 per order

• Tiers are set on 12-month volume and move up automatically

• Canadian stock, same-day dispatch, shipping included

Apply at durhampeptides.ca/wholesale and we come back within one business day. Single vials and multi-packs on this page are available to everyone at the prices shown — no account needed.