TB-500 Nasal Spray — 10mg

TB-500 is full-length Thymosin Beta-4, a 43-amino-acid peptide studied for its role in actin polymerisation and cellular migration. This nasal atomiser format supplies the same research-grade TB-500 stocked in vial form, packaged for intranasal research handling.

FULL-LENGTH TB-500 — NOT THE 17-23 FRAGMENT

This listing is the complete 43-amino-acid Thymosin Beta-4 peptide. Durham Peptides separately stocks TB-500 Frag 17-23, which contains only the seven-residue Ac-LKKTETQ actin-binding fragment taken from the middle of that sequence. The two are different materials and are not interchangeable in a protocol — if the work calls for the short fragment, order the TB-500 Frag 17-23 listing instead. This bottle contains the full-length peptide.

SHIPPED UNMIXED — AND WHY THAT MATTERS

Durham Peptides does not ship pre-diluted nasal sprays. Peptides in solution are materially less stable than in lyophilized form, so a bottle that is mixed at the warehouse begins losing potency the day it is filled and continues to do so in transit and in storage. Instead, the lyophilized peptide and the diluent travel separately and the researcher reconstitutes on arrival — which means full-strength material and a known, controlled in-use window rather than an unknown one.

Every nasal spray ships with sterile water preserved with 0.3% potassium sorbate, supplied specifically for this format. No separate bacteriostatic water purchase is required.

BENEFITS

• Ships unmixed — full-strength lyophilized material, not a solution degrading in transit

• Diluent included — sterile water with 0.3% potassium sorbate, no separate purchase needed

• Metered atomiser — consistent, repeatable delivery volume per actuation

• Full-length 43-amino-acid peptide — the complete Thymosin Beta-4 sequence, not the shortened fragment

• Verified identity — MS-confirmed against a Janoshik report you can check independently

WHAT RESEARCHERS LOOK AT

• Actin polymerisation and G-actin sequestration in cell-motility models

• Cellular migration and tissue-repair signalling in preclinical models

• Comparative activity against the shorter TB-500 Frag 17-23 in parallel study arms

• Intranasal versus parenteral delivery in comparative research models

• Post-reconstitution stability across the in-use window

QUICK SPECS

• Format: Metered nasal atomiser, supplied unmixed

• Form: Lyophilized peptide powder plus separate sterile diluent

• Net peptide per bottle: 10 mg

• Bottle volume: 10 mL

• Metered spray volume: 0.1 mL per actuation

• Sprays per bottle: approximately 100

• Concentration once reconstituted: 1 mg/mL

• Peptide per metered spray: 100 mcg (0.1 mg)

• Included diluent: Sterile water with 0.3% potassium sorbate

• Purity: ≥99% (HPLC verified)

• Identity: MS-verified (per COA)

• Storage: 2–8°C before and after reconstitution, protect from light

• Reconstitution: Diluent supplied — no separate bacteriostatic water required

IDENTITY BASICS

• Compound: TB-500 (full-length Thymosin Beta-4), CAS 77591-33-4

• Sequence length: 43-amino-acid peptide

• Molecular formula: C212H350N56O78S

• Molecular weight: 4963.44 g/mol

• Class: Full-length thymosin beta-4 peptide — not the Ac-LKKTETQ fragment

WHY CHOOSE DURHAM PEPTIDES FOR NASAL SPRAYS?

• Shipped unmixed for freshness — not pre-diluted at the warehouse

• Sterile diluent included in every bottle

• Janoshik tested with independently verifiable COA keys

• Same-day shipping across Canada (orders before 5:00 PM EST)

• Free shipping on orders over $200 CAD

• 100% vegan — synthetically manufactured, no animal derivatives

• Transparent Canadian pricing, shown above in CAD

DOES THE NASAL SPRAY COME PRE-MIXED?

No, and that is deliberate. Peptides are materially less stable in solution than in lyophilized form, so a pre-diluted bottle starts losing potency the day it is filled. Durham Peptides ships the lyophilized peptide and the sterile diluent separately so the researcher reconstitutes on arrival — full-strength material, and a known in-use window rather than an unknown one.

DO I NEED TO BUY BACTERIOSTATIC WATER SEPARATELY?

No. Every nasal spray ships with its own diluent — sterile water preserved with 0.3% potassium sorbate, supplied specifically for the atomiser format. This differs from the lyophilized vials in our catalogue, which are reconstituted with bacteriostatic water sold separately.

WHAT IS TB-500?

TB-500 is full-length Thymosin Beta-4, a 43-amino-acid peptide studied for its role in actin polymerisation and cellular migration. It is one of the more widely studied compounds in tissue-repair research models.

IS THIS THE FULL-LENGTH PEPTIDE OR THE 17-23 FRAGMENT?

This is the full-length peptide — all 43 amino acids of Thymosin Beta-4. Durham Peptides lists TB-500 Frag 17-23 as a separate product, and that one contains only the seven-residue Ac-LKKTETQ actin-binding fragment. They are different materials and are not interchangeable. If the protocol calls for the short fragment, order the TB-500 Frag 17-23 listing instead.

NASAL SPRAY VS VIAL — WHICH SHOULD I CHOOSE?

Both supply the same research-grade TB-500. The vial — TB-500 — 10mg — is the flexible option, since the researcher chooses the reconstitution volume and therefore the working concentration. The nasal atomiser is the convenience option, arriving with matched diluent and a metered actuator for consistent delivery volume. The choice depends on whether the protocol calls for a custom concentration or a repeatable fixed one.

HOW SHOULD IT BE STORED AFTER RECONSTITUTION?

Keep the bottle refrigerated at 2–8°C and protected from light both before and after reconstitution. Once reconstituted, use within an appropriate research timeframe — a peptide in solution has a materially shorter usable life than the sealed lyophilized material.

HOW IS IT SHIPPED IN CANADA?

Orders placed and paid before 5:00 PM EST ship the same business day via Canada Post Xpresspost with full tracking. Shipping is domestic from within Canada, so there are no customs delays or border holds.

IS THE COA VERIFIABLE?

Yes. Every batch is Janoshik-tested with a unique report key you can confirm independently — see our guide on how to verify a Janoshik unique key.

• For laboratory research use only.

• Not for human or veterinary use.

• Not intended for diagnosis, treatment, cure, or prevention of any disease.

• Use only in controlled laboratory settings by qualified personnel following appropriate safety procedures.