5-Amino-1MQ — 50mg

5-Amino-1MQ is a selective, membrane-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). Unlike most of the catalogue, it is not a peptide — it is a quinolinium compound, which is why it is supplied as a crystalline powder rather than a lyophilized peptide cake.

NNMT sits on the methylation branch of nicotinamide metabolism, which is why 5-Amino-1MQ appears in NAD+ salvage and adipocyte metabolism research. This 50mg presentation is the bulk research size — for researchers running extended or multi-arm work, it is materially better value per milligram than the 10mg vial. Researchers who only need a trial quantity should look at 5-Amino-1MQ 10mg instead.

BENEFITS

• Bulk research size — 5x the material of the standard vial, better cost per mg

• Selective inhibition — characterised as a selective NNMT inhibitor in published work

• Membrane-permeable — a property specifically noted in the foundational literature

• Small molecule — no reconstitution-stability profile of a peptide to manage

• Verified identity — MS-confirmed against a Janoshik report you can check independently

WHAT RESEARCHERS LOOK AT

• NNMT inhibition kinetics and selectivity against related methyltransferases

• Effects on the NAD+ salvage pathway and cellular NAD+ pools

• Adipocyte and skeletal-muscle metabolism in preclinical models

• SAM (S-adenosylmethionine) cycle modulation downstream of NNMT

• Dose–response characterisation across extended multi-arm study designs

QUICK SPECS

• Form: Crystalline powder (small molecule, not a lyophilized peptide)

• Net per vial: 50 mg

• Purity: ≥99% (HPLC verified)

• Identity: MS-verified (per COA)

• Storage: 2–8°C, protect from light and moisture

• Reconstitution: Use bacteriostatic water (sold separately)

IDENTITY BASICS

• Compound: 5-Amino-1-methylquinolin-1-ium iodide (5-Amino-1MQ), CAS 42464-96-0

• Class: Small-molecule NNMT inhibitor (quinolinium salt)

• Molecular formula: C10H11IN2 — molecular weight 286.11 g/mol

• Also written as: 5-amino-1MQ, NNMTi

WHY CHOOSE DURHAM PEPTIDES FOR 5-AMINO-1MQ?

• Janoshik tested with independently verifiable COA keys

• Bulk 50mg size stocked domestically — no split shipments

• Same-day shipping across Canada (orders before 5:00 PM EST)

• Free shipping on orders over $200 CAD

• Secure payment via Interac e-Transfer, credit/debit, or Crypto

• Transparent Canadian pricing, shown above in CAD

SELECTED RESEARCH

• Selective and membrane-permeable small molecule inhibitors of NNMT (PMC5826726)

WHAT IS 5-AMINO-1MQ?

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). It is not a peptide — it is a quinolinium compound, characterised in the literature as both selective and membrane-permeable, which is why it appears in NAD+ salvage and metabolic research.

5-AMINO-1MQ 50MG VS 10MG — WHICH SIZE?

The 50mg vial is the bulk research size and offers materially better value per milligram; it suits extended or multi-arm study designs. The 10mg vial is the trial size for pilot work or single-arm studies. The material is identical — only the quantity differs.

IS 5-AMINO-1MQ A PEPTIDE?

No. Despite usually being sold alongside research peptides, 5-Amino-1MQ is a small molecule — a quinolinium NNMT inhibitor. It is supplied as a crystalline powder rather than a lyophilized peptide cake, and does not share the handling profile of a peptide.

HOW SHOULD 5-AMINO-1MQ BE STORED AND RECONSTITUTED?

Store at 2–8°C, protected from light and moisture. Reconstitute with bacteriostatic water (sold separately) for research handling. Once reconstituted, keep refrigerated and use within an appropriate research timeframe.

HOW IS IT SHIPPED IN CANADA?

Orders placed and paid before 5:00 PM EST ship the same business day via Canada Post Xpresspost with full tracking. Shipping is domestic from within Canada, so there are no customs delays or border holds.

IS THE COA VERIFIABLE?

Yes. Every batch is Janoshik-tested with a unique report key you can confirm independently — see our guide on how to verify a Janoshik unique key.

• For laboratory research use only.

• Not for human or veterinary use.

• Not intended for diagnosis, treatment, cure, or prevention of any disease.

• Use only in controlled laboratory settings by qualified personnel following appropriate safety procedures.