Semax — 10mg

Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone fragment ACTH(4-10), developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. The C-terminal Pro-Gly-Pro tripeptide extension enhances metabolic stability and bioavailability compared to the native ACTH fragment. Semax has been the subject of extensive research in Russia, where it appears on the List of Vital & Essential Drugs, and has been studied in clinical settings for cerebrovascular and cognitive research. It is frequently studied alongside Selank, another Russian-developed neuropeptide.

BENEFITS

• Neurotrophic signaling — studied for BDNF (brain-derived neurotrophic factor) expression modulation

• Neuroprotection — investigated in cerebral ischemia and stroke models

• Cognitive research — explored for effects on learning, memory, and attention pathways

• Blood-brain barrier penetration — compact heptapeptide structure enables CNS access

• Well-characterized — decades of published research including clinical studies

WHAT RESEARCHERS LOOK AT

• BDNF and TrkB expression in hippocampal and cortical tissue models

• Neuroprotective effects in focal ischemia (pMCAO) models

• Monoaminergic neurotransmitter metabolism (serotonin, dopamine, norepinephrine)

• Gene expression profiling of immune and vascular systems post-ischemia

• Copper(II) chelation and amyloid-beta aggregation modulation

QUICK SPECS

• Form: Lyophilized peptide

• Net per vial: 10 mg

• Purity: ≥99% (HPLC verified)

• Identity: MS-verified (per COA)

• Storage: 2–8°C short-term, -20°C long-term, protect from light and moisture

• Reconstitution: Use bacteriostatic water (sold separately)

IDENTITY BASICS

• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (heptapeptide)

• Molecular Formula: C₃₇H₅₁N₉O₁₀S

• Molecular Weight: 813.92 g/mol

• CAS Number: 80714-61-0

• Common Synonyms: ACTH(4-7)-PGP, Semax Peptide

WHY CHOOSE DURHAM PEPTIDES FOR SEMAX?

• independently lab-tested with verifiable COA keys

• Same-day shipping across Canada (orders before 5:00 PM EST)

• Free shipping on orders over $200 CAD

• 100% vegan — synthetically manufactured, no animal derivatives

• Secure payment via Interac e-Transfer, credit/debit, or Crypto

SELECTED RESEARCH

• Dergunova et al. — Semax suppresses mRNA transcripts encoding proinflammatory mediators in rat brain ischemia: https://pubmed.ncbi.nlm.nih.gov/24708833/

• Dolotov et al. — Semax, an analog of ACTH(4-10) with cognitive enhancing properties: https://pubmed.ncbi.nlm.nih.gov/16996040/

• Agapova et al. — Effect of Semax on BDNF and TrkB gene expression in the hippocampus: https://pubmed.ncbi.nlm.nih.gov/18652270/

WHAT IS SEMAX?

Semax is a synthetic heptapeptide built from the ACTH(4-10) fragment with a Pro-Gly-Pro tail added to the C-terminus, an extension that markedly slows enzymatic degradation relative to the native fragment. It is studied in neuroprotection, BDNF expression and cognitive research models.

IS SEMAX AVAILABLE AS A NASAL SPRAY?

Yes. Semax Nasal Spray — 10mg supplies the same research-grade material in a 10 mL metered atomiser that delivers 0.1 mL per actuation. It ships unmixed with its own sterile diluent, so the researcher reconstitutes it on arrival rather than receiving a bottle that has been sitting pre-diluted. The vial remains the flexible format — you set the reconstitution volume and therefore the working concentration. The atomiser is the repeatable one.

WHAT IS THIS VIAL RECONSTITUTED WITH?

Bacteriostatic water, which is sold separately in our catalogue. The lyophilized powder is stable as shipped; once in solution its usable life shortens considerably, which is why it ships dry. Our nasal sprays differ on this point — each one includes its own sterile diluent, preserved with 0.3% potassium sorbate.

HOW SHOULD IT BE STORED?

Sealed and lyophilized, store at 2–8°C away from light; for long-term storage, −20°C is better. After reconstitution keep it refrigerated at 2–8°C and use it within an appropriate research timeframe — a peptide in solution has a materially shorter usable life than sealed lyophilized material.

IS THE COA VERIFIABLE?

Yes. Every batch is independently lab-tested with a unique report key you can confirm independently — see our guide on how to verify a lab report key.

HOW FAST DOES IT SHIP IN CANADA?

Orders placed and paid before 5:00 PM EST ship the same business day via Canada Post Xpresspost with full tracking. Shipping is domestic from within Canada, so there are no customs delays or border holds.

• For laboratory research use only.

• Not for human or veterinary use.

• Not intended for diagnosis, treatment, cure, or prevention of any disease.

• Use only in controlled laboratory settings by qualified personnel following appropriate safety procedures.

Volume discounts apply to your whole order, not to a single item. Enter the code at checkout.

• Spend $200 or more — 10% off with code VOLUME10

• Spend $500 or more — 15% off with code VOLUME15

• Spend $1,000 or more — 20% off with code VOLUME20

The thresholds are worth more than they look. A $499 order costs you $449. Add one more $20 vial to reach $500 and you pay $425 — more product, $24 less. Free shipping over $200.

Ordering at volume? The full catalogue is available at wholesale pricing through a five-tier programme.

• Minimum 10 units per product, any mix of products in one order

• Accounts open at $2,000 per order

• Tiers are set on 12-month volume and move up automatically

• Canadian stock, same-day dispatch, shipping included

Apply at durhampeptides.ca/wholesale and we come back within one business day. Single vials and multi-packs on this page are available to everyone at the prices shown — no account needed.